• Pharma/Biopharma
• Clinical Trials

Modeling and simulation are proven ways to address the high and unsustainable costs and time required for design and regulatory approval of increasingly complex healthcare solutions. By applying engineering simulation throughout development and the regulatory approval process, accelerates innovation, reduces cost and shortens time to market while meeting safety standards and product deadlines. With a patient’s well-being and even life at stake, product failure is not an option, simulation technology helps to maximize patient safety while making healthcare more affordable.

Comprehensive Modeling and Simulation Solutions for End-to-End Drug Manufacturing

• Discrete Event Simulation (DES) models material handling systems to optimize the flow of raw materials and reduce bottlenecks.
• Computational Fluid Dynamics (CFD) analyzes the flow and distribution of materials in silos, hoppers, and conveyors to prevent segregation and ensure uniformity.
• Reaction Kinetics Modeling simulates chemical reactions to optimize reaction conditions, yield, and purity.
• Process Simulation models entire synthesis processes, including reactors and separation units, to improve efficiency and scalability.
• Crystallization Modeling uses population balance models to predict crystal size distribution and optimize crystallization processes.
• Filtration Simulation models filtration processes to predict filter performance and optimize parameters.
• Chromatography Simulation models chromatographic separation to optimize column design and operating conditions.
• Mixing and Blending Simulation uses DEM (Discrete Element Method) to model the mixing of powders and granules to ensure uniformity.
• Granulation Modeling simulates granule formation processes, such as wet and dry granulation, to control particle size and distribution.
• Coating Simulation uses CFD and DEM to model the application of coatings on tablets or pellets, ensuring uniformity and desired release profiles.
• Spray Drying Simulation uses CFD to model the spray drying process, optimizing droplet size, airflow, and drying conditions.
• Tablet Compression Modeling uses finite element analysis (FEA) to simulate tablet compression, ensuring mechanical strength and dissolution properties.
• Thermal Sterilization Modeling uses heat transfer models to simulate the distribution of heat within autoclaves, ensuring complete sterilization.
• Packaging Simulation uses finite element analysis (FEA) and CFD to simulate packaging processes, ensuring product protection and stability during transport and storage.
• Process Analytical Technology (PAT) Modeling uses real-time data to create models that monitor and control manufacturing processes, ensuring product quality.